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William J Ledger Selected Research

Vulvar Vestibulitis

12/2014The bacterial microbiome in paired vaginal and vestibular samples from women with vulvar vestibulitis syndrome.
3/2009Polymorphism in a gene coding for the inflammasome component NALP3 and recurrent vulvovaginal candidiasis in women with vulvar vestibulitis syndrome.
1/2008Association between primary vulvar vestibulitis syndrome, defective induction of tumor necrosis factor-alpha, and carriage of the mannose-binding lectin codon 54 gene polymorphism.
9/2004Altered distribution of mannose-binding lectin alleles at exon I codon 54 in women with vulvar vestibulitis syndrome.
3/2004Immunoglobulin E antibodies to seminal fluid in women with vulvar vestibulitis syndrome: relation to onset and timing of symptoms.
3/2003Interleukin-1beta gene polymorphism in women with vulvar vestibulitis syndrome.
9/2002Differential characterization of women with vulvar vestibulitis syndrome.
4/2002Defective regulation of the proinflammatory immune response in women with vulvar vestibulitis syndrome.
3/2002A deficiency in interferon-alpha production in women with vulvar vestibulitis.

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William J Ledger Research Topics

Disease

9Vulvar Vestibulitis
12/2014 - 03/2002
8Infections
08/2013 - 09/2002
7Vulvovaginal Candidiasis
08/2015 - 09/2002
3Pain (Aches)
04/2017 - 03/2004
2Vulvodynia
04/2017 - 02/2015
2Bacterial Vaginosis
08/2015 - 05/2007
2Inflammation (Inflammations)
03/2013 - 03/2002
1Lichen Sclerosus et Atrophicus (Lichen Sclerosus)
05/2016
1Hyperalgesia
02/2015
1Ovarian Neoplasms (Ovarian Cancer)
04/2014
1Reproductive Tract Infections
08/2013
1Premature Birth (Birth, Premature)
08/2013
1Pruritus (Itching)
08/2009
1Streptococcal Infections (Streptococcal Infection)
12/2006
1Rupture
12/2006
1Sepsis (Septicemia)
12/2003
1Chronic Disease (Chronic Diseases)
04/2002
1Papillomavirus Infections
03/2002

Drug/Important Bio-Agent (IBA)

5Mannose-Binding Lectin (Mannan-Binding Lectin)IBA
01/2008 - 09/2003
4Codon (Codons)IBA
01/2008 - 09/2003
3Proteins (Proteins, Gene)FDA Link
04/2017 - 08/2013
3EnzymesIBA
04/2017 - 03/2004
3Anti-Bacterial Agents (Antibiotics)IBA
12/2010 - 12/2003
2Protease Inhibitors (Protease Inhibitor)IBA
02/2015 - 04/2014
2ImmunosorbentsIBA
02/2015 - 03/2004
2Interleukin-4 (Interleukin 4)IBA
05/2005 - 03/2004
2Interleukin-1beta (Interleukin 1 beta)IBA
03/2003 - 04/2002
2Interleukin-1 Receptors (Interleukin 1 Receptor)IBA
09/2002 - 04/2002
2LipopolysaccharidesIBA
04/2002 - 03/2002
1catechol (pyrocatechol)IBA
04/2017
1CatecholaminesIBA
04/2017
1Catechol O-Methyltransferase (Methyltransferase, Catechol)IBA
04/2017
1Adrenergic Agents (Adrenergic Drugs)IBA
04/2017
1DNA (Deoxyribonucleic Acid)IBA
04/2017
1Methionine (L-Methionine)FDA Link
04/2017
1Neurotransmitter Agents (Neurotransmitter)IBA
04/2017
1Testosterone (Sustanon)FDA Link
05/2016
1Lipocalin-2IBA
08/2015
1Secretory Leukocyte Peptidase InhibitorIBA
02/2015
1Peptide Hydrolases (Proteases)FDA Link
02/2015
1CathepsinsIBA
02/2015
116S Ribosomal RNAIBA
12/2014
1Biomarkers (Surrogate Marker)IBA
04/2014
1Lactic Acid (Lactate)FDA LinkGeneric
08/2013
1Matrix Metalloproteinases (MMPs)IBA
08/2013
1Metalloproteases (Metalloproteinases)IBA
08/2013
1Hyaluronic Acid (Hyaluronan)IBA
08/2009
1InterleukinsIBA
03/2009
1InflammasomesIBA
03/2009
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2008
1Nitric Oxide (Nitrogen Monoxide)FDA Link
05/2005
1AntibodiesIBA
03/2004
1Interleukin-12 (IL 12)IBA
03/2004
1Immunoglobulin E (IgE)IBA
03/2004
1Heat-Shock Proteins (Heat-Shock Protein)IBA
04/2002
1Interferon-gamma (Interferon, gamma)IBA
03/2002
1Interferon-alpha (Interferon Alfa)IBA
03/2002

Therapy/Procedure

1Menstrual Hygiene Products (Menstrual Pad)
03/2013
1Antibiotic Prophylaxis
04/2008
1Cesarean Section (Caesarean Section)
12/2006
1Intrauterine Devices (Intrauterine Device)
12/2006
1Vaginal Hysterectomy
12/2006
1Hysterectomy
12/2006